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Galectin Therapeutics galectin 1 levels
Galectin 1 Levels, supplied by Galectin Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/galectin-1/pm42316000-86-25-25
Average 86 stars, based on 1 article reviews
galectin 1 levels - by Bioz Stars, 2026-09
86/100 stars

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Expressing:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Transmission Assay:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Electron Microscopy:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Shear:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

In Vitro:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

In Vivo:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Fluorescence:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

In Situ:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Staining:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Immunofluorescence:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Activation Assay:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Binding Assay:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Glycoproteomics:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .

Biomarker Discovery:

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Galectin-1 (Gal1), the most abundant galectin, exhibits anti-inflammatory properties through its proapoptotic effect on activated T lymphocytes, promoting Th2 over Th1 responses and contributing to immune polarization.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: Based on the structural types: prototype galectins (e.g. Galectin-1, -2, -5, -7, -10, -11, -13, -14, -15) containing a single CRD and forming non-covalent homodimers, the Chimera-type galectin (Galectin-3) possessing a single CRD and oligomerizing via its N-terminal domain upon binding to glycan ligands, and Tandem-repeat galectins (e.g. Galectin-4, -6, -8, -9, -12) harboring two distinct CRDs connected by a flexible link and capable of forming higher-order multimers through interactions involving both their N- and C-terminal regions.

Article Title: A systematic review of the latest progress of drug resistance and clinical application of immunotherapy in renal cell carcinoma in the past five years based on bibliometrics
Article Snippet: Regarding the combination therapy of ICIs and tyrosine kinase inhibitors (TKIs), multi-omics analyses identified several key biomarkers: Galectin-1 expression correlates with treatment response and survival rates, though limited by small sample sizes and unclear mechanisms; low CDK5 expression and high CDK6 expression serve as independent prognostic markers and indicators of immunosuppressive microenvironments, respectively, supporting the rationale for CDK4/6 inhibitors in combination therapy, yet requiring validation through large-scale prospective studies., In drug resistance research, ANXA2 upregulation was linked to ICB+TKI resistance, while alternative complement pathway signatures (ACPS) and TROAP mutations could stratify treatment-responsive populations.

Article Title: Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness
Article Snippet: The involvement of galectins, especially Galectin-1 (Gal1) in the regulation of immune regulation makes them potential good candidate non-specific biomarkers of autoimmune diseases like RA.

Article Title: POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer
Article Snippet: Galectin-1( ) and hepatocyte growth factor ( ) were also confirmed as CAF-secreted proteins contributing to angiogenesis.

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Galectin‐1 administration effectively reduced cognitive dysfunction and suppressed microglial activation by downregulating IRAK1 expression, thereby diminishing neuroinflammation [ ].

Article Title: Microglial Modulation as a Therapeutic Avenue for Perioperative Neurocognitive Disorders: Unveiling Pathophysiological Mechanisms and Clinical Implications
Article Snippet: Modulation of microglial polarization , Anesthesia and surgery‐induced mouse PND model , Galectin‐1 treatment in aged mice after laparotomy improved cognitive function and reduced microglial activation by inhibiting IRAK1 expression , Shen et al. [ ] .

Article Title: Enhancing exosome stability and delivery with natural polymers to prevent intrauterine adhesions and promote endometrial regeneration: a review
Article Snippet: , High expression of Galectin-1 promotes macrophage polarization to M2 phenotype via JakSTAT signaling pathway. , IUAs mouse model , Relieve inflammation and improve fibrosis. , [ ] .



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